So we have concepts of sublethal injury, that may or may not be reversible, lethal injury...

So we have concepts of sublethal injury, that may or may not be reversible, lethal injury that causes a catastrophic break up of the cell, necrosis, or a more dainty and controlled form of programmed cell death known as apoptosis.

What are your thoughts about these types of injury - can you think of any examples? How you might expect them to manifest themselves!

Expert Solution

Necrosis, apoptosis are injuries constantly occuring in our body..Apoptosis is programmed cell death,it occurs during embryogenesis or whenever viral infection/malignancy occurs,whenever any change occurs intrinsic to cell,flippage of phospotidayl serine receptors occurs,it gives siganl to apoptosis, death receptors are present(TNF),these stimulate death domains inturn activates caspases..caspases cause apoptosis..in apoptosis cell membrane will be intact n there is no inflammation,in apoptosis cell shrinkage occurs..

In Necrosis..is caused by factors external to cell like infection,toxins,trauma..cause premature death of cell...in this cell membrane integrity is lost and inflammation is present around the surrounding tissue which leads to chemotaxis and cell death..during initial stages of necrosis it is reversible,after that it become irreversible..whenever cell injury occurs,hypoxia occurs..it leads to stoppage of Na+-k+ pump, Na+ accumulated along with water in cell, intially blebs formed,it is reversible..after that enzymes activated within cell causes pyknosis,karyorrhexis,karyolysis(it is irreversible)..cell death occurs..

Sydney Mullin answered 2 years ago

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