Question

detail how Wolff’s Law can explain an in increase in bone density, and also, how it can explain decrease in bone density.

Answer 1

Wolff’s law: “Every change in the function of a bone is followed by certain definite changes in its internal architecture and its external conformation."

If loading on a particular bone increases, the bone will remodel itself over time to become stronger to resist that sort of loading. The internal architecture of the trabeculae undergoes adaptive changes, followed by secondary changes to the external cortical portion of the bone, perhaps becoming thicker as a result.

If the loading on a bone decreases, the bone will become less dense and weaker due to the lack of the stimulus required for continued remodeling, lead to decreased bone density(osteopenia).

Eg, Astronauts who spend a long time in space will often return to Earth with weaker bones, since gravity hasn't been exerting a load on their bones. Their bodies have reabsorbed much of the mineral that was previously in their bones.

The raquet-holding arm bones of tennis players become much stronger than those of the other arm. Their bodies have strengthened the bones in their racquet-holding arm since it is routinely placed under higher than normal stresses.