In: Chemistry
In the manufacture of an active pharmaceutical ingredient (API), the API goes through a final purification step in which it is crystallized , filtered, and washed. The washed crystals contain 47 wt% water. They are fed to a tunnel dryer and leave the dryer at a rate of 165 kg/h containing 5% adhered moisture. Dry air enters the dryer at 145°F and 1 atm, and the outlet air is at 130°F and 1 atm with a relative humidity of 50%. Calculate the rate (kg/h) at which the API enters the dryer and the volumetric flow rate (ft3/h) of inlet air.
Given: The washed crystals contain 47 wt% water
Therefore % Crystal in feed, F = 100- 47 = 53 %
after passing through dryer the % of water = 5%
Therefore % Crystal in product = 100- 5 = 95 %
The flow rate of product = 165 kg/hr
So we can say that the amount (not percentage) of crystal will be same in the feed and the product
So flow rate of feed X % of crystal in feed = Product flow rate X % of crystal in product
F X 53 = 165 X 95 = 15675
F = 295.754 kg/hr
We may assume that flow rate of dry air = D Kg / hour, amount of water in air = W Kg / hour
flow rate of outlet air = (D+W) kg/hr
Again we can say that the total amount of water + crystal in the feed = total amount of water + crystal in product,
D + 295.754 = 165 + (D+W)
W = 130.754 kg/hr
also the temperature is
Tout = 135 oF = 330.37K
Tin = 145oF = 335.93 K
Here now we need standard data of pressure of saturated air
Psat at T = 16500 Pa
Ptotal = 1 atm = 101325 Pa
W/D = 0.5 X Psat / Ptotal
Putting values
D = 130.754 X 101325 / (0.5 X 16500) = 1605.896 kg/hr
using ideal gas equation
PV=nRT
P = pressure
V = volume
n = mass / Molecular weight
R = gas constant = 0.0821 L atm / mol K
T = tempearature = 335.93 K (Tin)
Rearranging
P X molecular weight /RT = Mass / Volume = density
Molecular weight of air = 28.97 g / mole
Density of air at Tin = P Mw / RT = 1 X 28.97 / (0.0821 X 335.93) = 1.05 g/L = 1.05Kg / m^3
Volumetric flow rate = D / Density = 1605.896 / 1.05 = 1529.42m3/hr
Now we have to convert m^3 to ft^3
= 1529.42 X3.283 ft3/hr = 53969.49ft3/hr