There is a protein called neurogenin that stimulates neuronal cells to differentiate. In order to determine...

There is a protein called neurogenin that stimulates neuronal cells to differentiate. In order to determine what kind of receptor neurogenin binds to, you add a general phosphatase (one that can remove phosphates from any substrate) to neural cells when you add neurogenin, and you discover that this inhibits differentiation. Furthermore, in the presence of this phosphatase, you find that not even a G protein is activated in response to neurogenin.

In a normal cell, why does the response to neurogenin cease over time?

Expert Solution

Neurogenins (Ngn) are the basic helix loop helix transcriptional factor that are critical for the neuronal differentiation. Different kinds of Neurogenin are present (Ngn1, 2, 3) that respond to diiferent pathway and they are regulated by variety of other regulatory protein. The activity of neurogenin involving its regulation by BMP (Bone Morphogenic factor), LIF (Leukemia Inhibitory factor) and Notch Signalling. However the timming of its expression depend on upregulation and downregulation of various factors/ regulatory proteins. The signalling through these regulatory protein in turn activitate the neurogenin to perform its specific function and these response with time tends to ceases as every normal cell has certain limit after which the process has to be ceases. After differentiation certain cells no longer response to signalling and the process of neurogenesis depend upon the specification of cells for neural differentiation, (regulated by Notch signaling) and the activity of neurogenic transcription factors such as neurogenin and NeuroD which drive the expression of neural gene. The inhibitory signal from these signalling pathway tends to ceases the response of neurogenin.

gladiator answered 2 years ago

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