Question

Using the methods discussed in class, show how to calculate the two one-locus allele frequency distributions for each of the loci in the population of white humans only. (b) (5 points) For the glycophorin B locus, show how to determine whether the S and s alleles are independently associated into genotypes in the population of white humans. Assume that the data above came from a sample of 1,000 individuals.

Answer 1

to check whether these genes assort independently  :

ASSUME : A GENE FOR human complexion

	genotype	phenotype
	AA	white
	Aa( A dominant heterozygous)	white
	aa ( recessive )	black

S gene for glycophorin B

	GENOTYPE	PHENOTYPE
	SS	normal glycophorin confirmation
	Ss (DOMINANT S)	normal glycophorin   confirmation
	ss	mutated Glycophorin confirmation

on crossing parent white and normal glycophorin (male) x black mutated glycophorin human ( female)

genotype AASS X aass

offspring AaSs (phenotype : white and normal glycophorin )

AaSs male mate to AaSs female

lead to following offspring with different cobination

BLACK,white , NG= NORMAL GLYCOPHORIN , MG= mutated glycophorin

	AS	As	aS	as
AS	AASS (white,NG)	AASs (white NG)	AaSS (white NG)	AaSs (white NG)
As	AASs(white, NG)	AAss (white MG)	AaSs (white NG)	Aass (white MG)
aS	AaSS (whiteNG)	AaSs (white NG)	aaSS (BLACK  NG)	aaSs (BLACK  NG)
as	AASs (white NG)	Aass(white  MG)	aaSs   (BLACKNG)	aass ( BLACK MG)

9: 3: 3:1 PHENOTYPIC RATIO: WHITE,NG: WHITE MG: BLACK NG: BLACK MG

1:2:1:2:4:2:1:2:1 = GENOTYPIC RATIO

THIS RATIO INDICATE THAT CONTRASTING CHARACTER I.E. ( WHITE, BLACK, NG,MG) BEHAVES INDEPENDENTLY AND BEAR NO ASSOCIATION WITH PARTICULAR CHARACTER