Question

Question1. Selective toxicity to microbes can minimize side-effects in antibiotics. Which of the following categories of drugs may show toxicity due to the binding of human mitochondrial 70S ribosomes?

A. Folate pathway inhibitors, like trimethoprim-sulfa

B. Drugs that interfere with the cell membrane, like daptomycin

C. Cell wall inhibitors, like beta-lactam antibiotics

D. Protein synthesis inhibitors, like aminoglycosides

E. Nucleic acid inhibitors, like fluoroquinolones

Question #2. Please fill in the blanks with the appropriate name of the respiratory or digestive disease. Use the word bank below to choose the correct names.

tuberculosis pneumonia otitis media hepatitis A dental caries

glomerulonephritis colitis influenza hepatitis C gastroenteritis

A. In the disease, ------------------------ , acid eats away at the enamel on the crown of the tooth.

----------------------- , is defined as infection and inflammation of the lungs (alveoli).

B. In the disease, --------------------- , antigenic shifts can lead to severe pandemic outbreaks.

C. In the disease, Streptococcal pharyngitis, rare complications such as the kidney disease, ----------------------- , can occur.

D. Campylobacter, E. coli and Salmonella can cause bacterial -------------------------- which can lead to vomiting, diarrhea, cramps

and possible fever.

E. In the disease, ------------------------------------ , fecal-oral spread can lead to jaundice.

F. In the disease --------------------------- , granulomas form, and patients can be latent or active.

G. In the disease, C diff, endospore-forming bacteria take over the intestines, causing diarrhea, leading to the possible complication called pseudomembranous --------------------------.

H. In the disease, common cold, one possible complication is ear infection, also known as -----------------------------------.

I. In the disease, -------------------------------- , over 80% of cases go chronic and can suffer long-term complications such as cirrhosis and liver failure.

Answer 1

1)

The category of drugs that may show toxicity due to the binding of human mitochondrial 70S ribosomes is the

Protein synthesis inhibitors, like aminoglycosides. Since, they have affinity to bind to the 70S ribosomes.

Examples of aminoglycosides include, Streptomycin, Kanamycin.

2)

A) In the disease, dental caries , acid eats away at the enamel on the crown of the tooth. Pneumonia is defined as infection and inflammation of the lungs (alveoli).

B) In the disease influenza, antigenic shifts can lead to severe pandemic outbreaks.

C) In the disease, Streptococcal pharyngitis, rare complications such as kidney disease, glomerulonephritis can occur.

D) Campylobacter, E. Coli and Salmonella can cause bacterial colitis which can lead to vomitting, diarrhoea cramps and possible fever.

E) In the disease, Hepatitis A fecal oral spread can lead to jaundice.

F) In the disease, tuberculosis granulomas form and patients can be latent or active.

G) In the diseas C, diff, endospore-forming bacteria take over the intestines, causing diarrhoea leading to the possible complication called pseudomembranous gastroentritis.

H) In the disease common cold, one possible complication is ear infection, also known as otitis media.

I) In the disease, Hepatitis C over 80% of cases go chronic and can suffer long-term complications such as cirrhosis and liver failure.