Question

In: Biology

true or False 1) wee1 Chinese is a positive regulator of Mpahse. 2) TAU is important...

true or False

1) wee1 Chinese is a positive regulator of Mpahse.
2) TAU is important for binding to Acton to help stabilization.

Solutions

Expert Solution

Statement 1 is False.

Wee1 Kinase is not a positive regulator of M phase (Mitosis phase). Rather it is a negative regulator of M-Phase. It regulates the entry of a cell in to mitosis. Wee1 kinase regulates mitosis by phosphorylation of tyrosine residues at two points (Tyr 14 and Tyr 15) in cyclin-dependent kinase-1 (Cdk1) which results in to lowering the efficiency of Cdk1 and hence, cell entry into M-phase is checked. However, when several other regulators decrease the activity of Wee1, Cdk1 kinase activity is high and cell enters in to M-phase.

Above mechanism of Wee1 function indicates that Wee1 is negative regulator of M-phase.

Statement 2 is False

Tau protein, a product of MAPT gene, is largely known for maintaining the microtubule stability. As Microtubule is made up of tubulin, tau protein interacts with tubulin so that it stabilize and assemble tubulin into microtubules.

On the other hand, actin protein is the component of microfilament and tau protein does not play any role in assembly or stabilization of actin (or microfilament). Hence statement 2 is also False.

gladiator answered 2 years ago
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