1.) A.) CTP stablizes the R or T state? (pick one) of aspartate carbamoyl transferase (ACTase)...

1.) A.) CTP stablizes the R or T state? (pick one) of aspartate carbamoyl transferase (ACTase) and acts as a:

a.) positive regulator b.) negative regulator c.) a co-factor d.) competitive inhibitor

B.) regulation of ACTase results in equal numbers of synthesized purines and pyrimidines. explain how this occurs.

C.) What would be the shape of the michaelis-menten curve for this enzyme (like parabolic, sigmoidal,etc)?

Expert Solution

A. CTP (Cytidine triphosphate) acts as an allosteric inhibitor and inhibits the activity of aspartate carbamoyl transferase (ATCase) and stabilizes the T - state of aspartate transcarbamoylase. Hence CTP stabilizes the T - state.

Since CTP inhibits the activity of aspartate carbamoyl transferase (ATCase), hence CTP and ATCase act as negative regulator.

B. aspartate carbamoyl transferase (ATCase) catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoyl aspartate which is the first step in the biosynthesis of pyrimidine.

The activity of ATCase is positively regulated by ATP through allosteric regulation, where as the activity of ATCase is negatively regualted by CTP through allosteric regulation. Hence the positive and negative regulation by ATP and CTP respectively results in the synthesis of equal number of purines and pyrimidines.

C. Here the michaelis-menten curve obtained for the activity of ACTase is a sigmoid curve because, the activity of aspartate carbamoyl transferase (ATCase) is allosterically regulated by 2 different substances (ATP and CTP) that follow michaelis-menten equation independently and give give parabolic curve.

When we combine these two parabolic curves, we get a sigmoid cure.

queen_honey_blossom answered 3 hours ago

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