The most important known inhibitors of the ETC are: ? Amytal ? Rotenone ? Antimycin A...

The most important known inhibitors of the ETC are:

? Amytal

? Rotenone

? Antimycin A

? CO

? Sodium Azide

? Cyanides

Indicate the nature of each of these inhibitors (what are they?), and how/where do they exert their effect on ETC.

Expert Solution

Amytal: Amytal is a barbiturate which is used as insecticide. It blocks electron transport chain (ETC) between NADH dehydrogenase (Complex I) and CoQ.

Rotenone: It is a plant product which is used as pesticide. It also blocks electron transport chain (ETC) between NADH dehydrogenase (Complex I) and CoQ.

Antimycin A: It is an antibiotic obtained from Streptomyces griseous and uses for controlling some fish species. Antymicine A interferes with electron flow from cytochrome bH in Complex III (Q-cytochrome c oxidoreductase).

Carbon monoxide (CO): CO is colourless and odourless gas which is produced by incomplete combustion of fuels (engine and furnace exhausts are important sources). CO binds to the reduced form of iron in Hem groups (Fe++) in cytochrome Oxidase.

Cynaides: Cyanide is a gas mostly produced by indutrial or residential fire. Cyanide affects almost all metalloenzymes, but its main toxicity arises due to the binding with Fe+++ in the Hem groups in cytochrome Oxidase, inhibiting the functioning of the Electron Transport Chain.

Sodium azide: Sodium azide is inorganic compound used as propellants in airbags. It is also used as detonator in explosive industry. Sodium azide act similarily as cyanide.

gladiator answered 2 years ago

List the inhibitors of ETC , Oxidative phosphorylation and their specific targets / (actions) describe briefly

The antibiotics puromycin and erythromycin are known inhibitors of protein synthesis. (a) Which part of...

The antibiotics puromycin and erythromycin are known inhibitors of protein synthesis. (a) Which part of the protein synthesis is affected by each antibiotic? (b) What could be the reason why one of them is more effective than the other one when they are given in the same dose?

.One of the most important and well known reform act passed in response to the Financial...

.One of the most important and well known reform act passed in response to the Financial Crisis of 2007-2009 was the Dodd-Frank Wall Street Reform and Consumer Protection Act, popularly called the Dodd-Frank Act. Explain 2 specific provisionsof this Act and the purpose it was designed to fulfill? b. One goal of the Dodd-Frank Wall Street reform is to end the too-big-to-fail problem. How did it propose to do so? Why might it fail?

Are there any known inhibitors of hexokinase (highlight at least one and describe how it works)?

What are some known inhibitors of photosynthesis and indicate at what location(s) precisely in the electron...

What are some known inhibitors of photosynthesis and indicate at what location(s) precisely in the electron transfer reactions of photosynthesis does this compound inhibit. Provide at least one such compound.

There’s a class of drugs used to treat high blood pressure known as ACE-Inhibitors. As you...

There’s a class of drugs used to treat high blood pressure known as ACE-Inhibitors. As you might guess from the name, these drugs work by inhibiting the enzyme ACE. a. Explain in detail how an ACE-inhibitor would work to lower blood pressure. (5 points) b. What effect will ACE-inhibitors have on the volume of urine produced? Explain why. (3 points)

Compare and contrast the different types of inhibitors, with examples, including: transition state inhibitors, suicide inhibitors,...

Compare and contrast the different types of inhibitors, with examples, including: transition state inhibitors, suicide inhibitors, irreversible inhibitors, competitive and noncompetitive inhibitors

Which is NOT a medication used to treat HIV? protease inhibitors antibiotics fusion inhibitors integrase inhibitors...

Which is NOT a medication used to treat HIV? protease inhibitors antibiotics fusion inhibitors integrase inhibitors antibodies that bind CD4 on T-helper cells

One of the most important, if not the most important aspect of portfolio analysis is that...

One of the most important, if not the most important aspect of portfolio analysis is that of “Performance Evaluation”, therefore it is very important that investments practitioners utilize the different methods of performance evaluation to understand the results which were generated. Do you agree or disagree, provide detailed information to support.

what is the most important thing of opportunity cost? what is the most important thing of...

what is the most important thing of opportunity cost? what is the most important thing of scarcity in economic ?

Question