Question

Describe the contraindications that must be addressed prior to the administration of alteplase.

Answer 1

The contraindications that must be addressed prior to the administration of alteplase

Contraindications

Hypersensitivity to alteplase or any component of the formulation

Treatment of STEMI or PE: Active internal bleeding; history of recent stroke; recent (within 3 months or 2 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding (eg, intracranial neoplasm, arteriovenous malformation, aneurysm); known bleeding diathesis; severe uncontrolled hypertension unresponsive to emergency therapy).

Additional absolute contraindications include; active bleeding (excluding menses); any prior intracranial hemorrhage; suspected aortic dissection; ischemic stroke within 3 months except when within 4.5 hours; significant closed head or facial trauma within 3 months with radiographic evidence of bony fracture or brain injury