Question

Distinguish between the four main types of drug antagonists. Provide an example of an irreversible antagonist. Please answer this question in one paragraph with more detail

Answer 1

Types of antagonists

1)Chemical antagonist

2)physiological antagonist

3)pharmacological antagonist

4)Allosteric antagonist

*chemical antagonist -it is a type of antagonist that binds to a drug or ligand and renders it ineffective. A chemical antagonist does so by causing certain chemical changes in the ligands it binds. The antagonist binds to the agonist and forms an inactive complex that cannot perform any function.

*physiological antagonist -it is a type of antagonist that binds to a separate receptor and counters the effect of antagonist. Two drugs should be physiologically antagonist of one another if they bind to two different receptors and produce to opposite effects.

*pharmacological antagonist -they binds to the same receptor as the agonist does. It occupies the binding site of the receptor and prevents yhe binding of agonir to the receptor.

*Allosteric antagonist - it is a type of antgonist that binds to the receptor but on a different site as compared to the binding site of real antagonist. Binding of allosteric antagonist induces changes in receptor.

2)Phenoxybenzamine is an irreversible antagonist of alpha receptor.