7. Distinguish between broad-spectrum and narrow-spectrum antimicrobials?

Expert Solution

Broad spectrum antimicrobials:

Effective against more than one group of bacteria
Broad spectrum antimicrobial agents can be administered when there is serious systemic infections and there is no time to determine causative agent
It is frequently used as empiric therapy to cover a wide range of potential pathogens
It can be administered when narrow spectrum antimicrobials fails for treatment or prevention of infections
It can be used for polymicrobic infections or as prophylactic measures
Examples of broad spectrum antimicrobials are aminoglycosides, second and third generation cephalosporins

Narrow spectrum antimicrobials:

Target a specific group of pathogens
Use of narrow spectrum antimicrobials preferred to avoid superinfection and development of resistance
It is used for the specific infection when the causative organism is known for particular infection
It is used to minimize collateral damage to the normal microbiota
The examples of narrow spectrum antimicrobials are older penicillins, vancomycin

Nightingale answered 2 years ago

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7. Distinguish between broad-spectrum and narrow-spectrum antimicrobials?

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