Question

“Mutations present within a single gene can be rescued if they are located in a certain distance from each other” discuss. What would be the rescue scenario if the mutations overlap?

Answer 1

Mutation is a change in the nucleotide sequence of a short region of a genome.Single gene or Mendelian disorders result from errors in DNA sequence of a gene and include autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant and Y-linked disorders.

In autosomal dominant disorders ,damage in one allele of a pair of the gene leads to the deficiency.Mutations in both alleles of a gene are required to cause the defect to appear in an autosomal recessive disorder.

In an X-linked disorder, the mutated gene is located on the X chromosome. A recessive mutation can lead to the disease. The gene in chromosome X should be mutated to cause the condition. An X-linked recessive disorder is carried by females but usally affects males.

Multiple Overlapping Genetic Codes Profoundly Reduce the Probability of Beneficial Mutation.There is growing evidence that much of the DNA in higher genomes is poly-functional, with the same nucleotide contributing to more than one type of code.

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