Question

In: Biology

The synthesis of lipids in cancer cells is dependent upon mitochondrial citrate, which is derived from...

The synthesis of lipids in cancer cells is dependent upon mitochondrial citrate, which is derived from both glucose and glutamine.

A)  True    

B)  False

Solutions

Expert Solution

The statement is true. Cancer cells can utilise both glucose and glutamine in synthesis of lipids. The glucose through glycolysis converts to pyruvate. This pyruvate, then transforms into Acetyl-CoA. Acetyl-CoA enters Krebs' cycle and forms citrate. The citrate is then used to produce lipids.

When mitochondrial respiration is limited, anaplerosis occurs. Anaplerosis is metabolism of glutamine. Glutamine first gets converted into oxaloacetate. From it, the citrate is formed. Citrate from both the processes helps in the lipd biosynthesis. Thus, by altering such metabolic pathways, the nutrient requirements of cancer cells are met.


Related Solutions

The synthesis of lipids in cancer cells is dependent upon mitochondrial citrate, which is derived from...
The synthesis of lipids in cancer cells is dependent upon mitochondrial citrate, which is derived from both glucose and glutamine. A)  True     B)  False
Cell Cancer: a. In what ways are cancer cells different from normal cells in terms of...
Cell Cancer: a. In what ways are cancer cells different from normal cells in terms of properties and behavior? b. What is the difference between an oncogene and a tumor suppressor gene?
14. If cancer cells from breast cancer enter the lymphatics of the breast, where are they...
14. If cancer cells from breast cancer enter the lymphatics of the breast, where are they likely to lodge and start new growths? Explain why, using your knowledge of the anatomy of the lymphatic and circulatory systems. 19. Explain why lymphedema may occur after breast surgery. 5. What is the function of interferon? 14. What are cytokines? Lymphotoxins? 10. Briefly, what role, if any, does each of the following hormones play when the body id subjected to stress: ACTH, ADH,...
In an experiment to isolate the lipids from horse red blood cells, one of the steps...
In an experiment to isolate the lipids from horse red blood cells, one of the steps is too "Add 500µL of 10mM sodium phosphate buffer (pH. 7.0). Resuspend the pellet thoroughly by vortexing." What happens in this step of the lipid isolation period? (hint: the supernatant in the next centrifuge step will be red)
Upon being secreted from the pancreas, glucagon binds to the receptors on liver cells, which initiates...
Upon being secreted from the pancreas, glucagon binds to the receptors on liver cells, which initiates a signaling cascade that regulates glycogen metabolism, glycolysis/gluconeogenesis, and fatty acid metabolism. Explain the following: 1. The metabolic conditions in which glucagon is released from the pancreas 2. How it affects metabolism of glycogen, glucose (glycolysis/gluconeogenesis), and fatty acids 3. Why it makes metabolic sense for glucagon to regulate these pathways in this manner in the liver cells.
Describe the six characteristics that cancer cells acquire, or lose, as they transform from normal cells....
Describe the six characteristics that cancer cells acquire, or lose, as they transform from normal cells. Provide an example for each characteristic and describe the types of DNA changes that may occur to cause such protein changes.
Synthesis of soap from lipids lab 1. Propose a reasonable explanation for why soaps form scums...
Synthesis of soap from lipids lab 1. Propose a reasonable explanation for why soaps form scums with ions like Ca2+ but not with Na+. 2. Compare the previous results with the test with tap water. Do you believe you have hard or soft water in your area?
Which DNA polymerase is responsible for the bulk of DNA synthesis in E.coli cells? Which DNA...
Which DNA polymerase is responsible for the bulk of DNA synthesis in E.coli cells? Which DNA polymerase was identified first? Define “processivity”. A. Pol III; Pol I; How long the DNA polymerase complex continues to catalyze chain extension before detachment from DNA B. Pol I; Pol II; The stability of a DNA polymerase molecule in an E. coli cell C. Pol II; Pol I; How many DNA chains the polymerase can synthesize in 60 min D. Pol I; Pol III;...
Kinetic Properties of a Key Enzyme of Prostaglandin Synthesis Prostaglandins are derived from the 20-carbon fatty...
Kinetic Properties of a Key Enzyme of Prostaglandin Synthesis Prostaglandins are derived from the 20-carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin endoperoxide synthase. The enzyme converts arachidonic acid to PGG2, the immediate precursor for many prostaglandins. The table below show the result of enzyme activity with or without an inhibitor, ibuprofen. You need first to determine the Vmax and Km, with and without the inhibitor, and then determine which type of inhibitor Ibuprofen is.  ...
In an experiment, where we need to isolate lipids from horse red blood cells, one of...
In an experiment, where we need to isolate lipids from horse red blood cells, one of the steps is too "Add 100µL of choloform;methanol (9:1) and mix vigorously to dissolve the membrane lipids. " What happens in this step, what would happen if you added water instead of chloroform/methanol?
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT