Place the following translation termination events into the order of their occurrence:

1. The release factor signals the release the nascent peptide from the P site tRNA.

2. Dissociation of the mRNA and the last deacetylated tRNA occurs from the ribosomal subunits.

3. Recognition of the stop codon by a release factor that binds in the A site.

4. Translocation of the ribosome along the mRNA to place a stop codon in the A site.

A. 3, 4, 2,1 B. 1, 2, 3, 4 C.4, 3, 2, 1 D. 1,3, 4,2 E. 4, 3, 1,2

Solutions

Expert Solution

Option E.

As translation continues, tRNA carrying the amino acid, binds at the A site of the ribosome. Finally the ribosome encounters the stop codon and translation terminates. The stop codon is placed at the A site of the ribosome. There is no tRNA which will recognize the stop codon, instead this stop codon is recognized by a Release factor. In the next step this release factor, with the help of a water molecule, will cause release of the polypeptide from the P site of the ribosome, and finally, the mRNA, ribosome and tRNA will dissociate to complete the termination process.

gladiator answered 1 year ago

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