In: Nursing
GIGANTISM refers to abnormally high linear growth due to
excessive action of insulinlike growth factor-1 (IGF-1) while the
epiphyseal growth plates are open during childhood. ACROMEGALY is
the same disorder of IGF-1 excess but occurs after the growth plate
cartilage fuses in adulthood.
In other words, gigantism is in the skeletally immature and is
proportional whereas acromegaly occurs in skeletally mature people
and only affects those bones that can keep growing.
Etiology and risk factors
Hyperpituitarism is defined as oversecretion of one or more of the hormones secreted by the pituitary gland it is caused primarily by a hormone secreting pituitary tumor, typically a benign adenoma. Syndromes associated with Hyperpituitarism are Cushing's syndrome, acromegaly, galactorrhea and so on.
Pathophysiology
Prolactin and growth hormone are the hormones most commonly overproduced by adenomas. They lead to hyperprolactinemia and acromegaly. Increased amounts of growth hormone lead to rapid growth of all body tissues. This increased growth leads to gigantism. If it occurs before closure of the epiphysis and acromegaly if it occurs after epiphyseal closure.
... Clinical manifestations of acromegaly.
Headache
Diplopia
Lethargy
Blindness
Goiter
Broadening of hands and feet due to gross increase in soft tissue
Increased ring and shoe size
Enlargement of visceral organs
Thickening of skull protruding supra orbital ridges.
Ciaresining of facial features.
Prognathism causing underbite
Cardiomyopathy
Diabetic mellitus
Enlaged but weak skeletal muscles
Thickened heel pads
.........................
Clinical features of gigantism
Excessive growth
The child is large for their age
Delayed puberty
Double vision or difficult with peripheral vision
Headache
Increased sweating
Large hands and feet
Thickening of facial features
Weakness
So these are difference of acromegaly and gigantism. Oversecretion of growth hormone usually from the pituitary, starting between the ages of 20 and 40,this is acromegaly.oversecretion of growth hormone usually from the pituitary, starting in childhood before fusion of the growth plates of bone,is gigantism.