Question

2)Which ONE of the following is NOT a property of the transformed phenotype:

a)Induced by over expression of tumor suppressor genes

b)Anchorage independence

c)Infinite proliferative life span

d)Lower requirement for growth factors

e)Does not exhibit density-dependent inhibition of cell growth

3)Which ONE of the following is NOT true about DNA viruses and cancer:

a)HPV E6, HPV E7 and SV40 large T antigen are all viral oncoproteins encoded by DNA viruses

b)they encode viral oncoproteins that bind RB

c)viral oncoproteins do not originate from host genes

d)they encode viral oncoproteins that bind MDM2

4) Which ONE of the following is NOT TRUE about the JNK pathway:

a)Another name for the pathway is the stress activated pathway (SAPK)

b)JNK stands for Jun N-terminal kinase

c)It is activated by UV and osmolarity changes

d)it does not require scaffolding proteins for proper signaling

e)it is affected by phytochemicals such as resveratrol

5)Which ONE of the following is NOT TRUE about the online resources The Cancer Genome Atlas (TCGA) and cBioPortal:

a)they can help researchers understand the molecular basis of cancer

b)they can help distinguish tumor subtypes for better diagnosis

c) they allow many scientists around the world to access the data and further cancer research

d) they can help the average person diagnose themselves in the comfort of their own home

e) they can help identify genomic characteristics of tumors to improve treatment

6) Which ONE of the following statements is NOT TRUE about Ras signaling:

a)GEFs (guanine nucleotide exchange factors) convert inactive Ras to active Ras

b)Ras was identified in both the NIH 3T3 foci assay and as a viral oncogene

c)active Ras recruits Raf to the inner plasma membrane

d)~50% of Ras is bound to GTP in the active state in a normal cell

e)prenylation of its C-terminal tail is required for both wt and mutant Ras to be functional

Answer 1

2. The statement that is not a property of transformed phenotype is : a)Induced by over expression of tumor suppressor genes. In transformed phenotypes the tumor supressor genes are inhibited or supressed but over expression of the tumor supressor genes doesnt cause the cancer and hence is not a property of transformed phenotype.

3. The statement that is not true about DNA viruses and cancer is : d)they encode viral oncoproteins that bind MDM2. The MDM2 binds to both Rb and p53 gene and the viral oncoproteins bind to these two Rb and p53 but donot bind to the MDM2 protein directly,

4. The statement that is not true about JNK pathway is: d)it does not require scaffolding proteins for proper signaling. The JNK pathway require scaffolding proteins such as the JIP proteins for proper signalling.

5. The statement that is not true about the cancer genome atlas and cBioportal is: d) they can help the average person diagnose themselves in the comfort of their own home.

6. The statement that is not true about Ras signalling is: d)~50% of Ras is bound to GTP in the active state in a normal cell

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