What kind of damage UV light is causing in DNA? What effect this damage has on...

What kind of damage UV light is causing in DNA? What effect this damage has on the cell growth?

Solutions

Expert Solution

UVB light (315-280 nm) interferes directly with the bonding in DNA molecule between the nucleotides, leading to the formation of photochemical products. (eg-CPD, 6,4 PP)

Eg- cyclo butane pyrimidine dimer (CPDs) formed when two adjacent pyrimidines (thymines or cytosines) become linked covalently creating an intermediate, thymine dimmers, that is not normally found in DNA. They form causes a structural kink in the DNA that prevents the DNA replication (as it interfere with basepairing of pyrimidine). The mutation induced by UVB is C to T transversion.

Eg. 6-4 Photo Products are formed due to covalent bond between adjacent pyramidines (the 5’ end of C6 and 3’ end of C4). This lead to the formation of an unstable intermediate , thus form a kink in DNA , interfere with normal base pairing thereby replication.

On exposure to UV A radiation free radicals are produced in cells that oxidise DNA bases . The modified bases fail to correctly pair during replication and creates mutation.

Effect on cell growth

Damages in DNA sequences lead to formation of skin cancer. Melanoma is the most serious type of skin cancer that develop in melanocytes.

Programmed cell death (apoptosis) induced by UV-C light

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Illustrate the biochemical mechanism and the effect of UV in DNA (in detail). Draw your own...

Illustrate the biochemical mechanism and the effect of UV in DNA (in detail). Draw your own figure to explain your answer.

What is the energy of a single photon of the UV light that was emitted?

A black light produces UV light with wavelengths below 400 nm. When the chemical quinine (which is in tonic water) is exposed to light with a wavelength of 383 nm, it becomes excited and then re-emits light at 450. nm. Is the re-emitted light lower or higher energy than the light that was absorbed? Is it lower or higher frequency? Answer this question without a calculation. What is the energy of a single photon of the UV light that was...

What property allowed us to observe analgesics under the UV light?

In your own words what kind of economic effect has Obama Care had, and what effect...

In your own words what kind of economic effect has Obama Care had, and what effect will it have going forward, on the US? Think about unemployment, inflation, GDP, productivity etc., and remember to keep all discussions on a civil and Christ-like level.

11. What characteristics of a molecule make it likely to absorb UV light in an analytically...

11. What characteristics of a molecule make it likely to absorb UV light in an analytically useful region of the UV spectrum (>185 nm)? 12. Why is it not typical to analyze molecules with absorbance spectrophotometry if they do only absorb light <185 nm.

What kind of a macromolecule is DNA? What is the chemical reaction involved in the precipitation...

What kind of a macromolecule is DNA? What is the chemical reaction involved in the precipitation of DNA? Why is it important to extract DNA?

What do NER and BER stand for, what kind of damage do each of them repairs?...

What do NER and BER stand for, what kind of damage do each of them repairs? Briefly, how do they repair the damage?

Which UV light hits earth's surface at the greatest intensity?

“Pollution is causing $100 million worth of damage to the environment and we are only spending...

“Pollution is causing $100 million worth of damage to the environment and we are only spending $1 million to reduce pollution. We are clearly not spending enough on fighting pollution.” Analyse and comment on this statement in a Macroeconomics context.

One photon or particle of light has enough energy to cause biological damage if the particular...

One photon or particle of light has enough energy to cause biological damage if the particular form of electromagnetic radiation is ultraviolet UV light, an X-ray or a gamma ray. There have been some claims that the use of cell phones causes brain damage. (We’re talking about physical damage from irradiation not psychological dependence or a car crash while dialling.) Search reference materials or use the Internet to find out where cell phones fit on the energy scale. Use the...

Subjects