Question

PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

True or False

Answer 1

PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

False.

PLC mediates the cleavage of phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Increased activation of PLC has great impact on the reduction of PIP2 that anchor in membrane or allosteric regulator. IP3 along with DAG acts as a secondary messenger in signal transduction. IP3 can diffuses into the cell and binds to receptor of the calcium channel located inside the membrane where DAG stays inside the membrane. IP3 regulates various calcium intercellular signalling. Phospholipse D (PLD) belongs to the phospholipase enzyme superfamily. The major role of PLD is acting as substrate for phosphatidylcholine which produce phosphatidic acid (PA), a signal moleccule and also the soluble choline.