Question

Kathy is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but states that “it does not help” and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.

a) Kathy expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks?

b) Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different.

Answer 1

Side Effects of Celecoxib
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using celecoxib and call your doctor at once if you have a serious side effect such as:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
swelling or rapid weight gain;
urinating less than usual or not at all;
nausea, upper stomach pain

Preacautions
NSAID use increased the risk of MI, hospitalization for heart failure, and death.Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of celecoxib may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers
Avoid the use of CELEBREX in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure. If CELEBREX is used in patients with severe heart failure, monitor patients for signs of worsening heart failure.
Advise patients to be alert for the symptoms of cardiovascular thrombotic events, including chest pain, shortness of breath, weakness, or slurring of speech, and to report any of these symptoms to their health care provider immediately
Advise patients to be alert for the symptoms of congestive heart failure including shortness of breath, unexplained weight gain, or edema and to contact their healthcare provider if such symptoms occur .

Differences between ibuprofen and Celebrex

ibuprofen

⦁ Relieves pain, fever, and swelling.

⦁ Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.

⦁ Advil (ibuprofen) is effective for treating fever, pain, and inflammation.

⦁ Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.

⦁ Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.

⦁ Advil (ibuprofen) causes less stomach problems than its alternatives.

⦁ It comes in different flavored liquid forms that makes it easy for children to take.

⦁ Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.

⦁ It needs to be taken with food or millk to avoid getting an upset stomach.

⦁ Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.

⦁ It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.

⦁ Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.

⦁ Used for Migraine headache ,Migraine prevention,Gout

Celebrex

⦁ Relieves pain and inflammation.

⦁ Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.

⦁ Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.

⦁ Good for treating muscle aches and pains, as well as menstrual cramps.

⦁ Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.

⦁ Lasts longer than Ibuprofen.

⦁ The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.

⦁ Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.

⦁ Can also affect your kidneys or cause permanent kidney damage if taken for a long time.

⦁ used for Gout, Colorectal polyp prevention for people with high risk,Coronary stent blockage prevention