Question

1. Provide details for the synthesis, storage and release of ACh (150-word limit). Please provide detail

Answer 1

Synthesis:

1. Acetylcholine is an organic chemical function as neurotransmitter in the brain and body.

2. For the synthesis of ACh- choline, and Co. A is required which is with the help of an enzyme choline acetyltransferase converted to acetylcholine in neurons.

3. The enzyme acetylcholine transferase converts acetylcholine into the inactive metabolites choline and acetate.

4. Acetylcholine transferase enzyme found in the synaptic cleft.

Storage:

1. Acetylcholine is stored at the end of acetylcholine producing neurons called cholinergic neurons.

2. It is stored until the neurotransmitter needs to be released. It gets packed into vesicles after synthesis.

3. Acetylcholine is transferred from cytoplasm to vesicle by transport protein known as vesicular acetylcholine transporter.

Release:

1. When nerve impulse arrives at the terminal of motor neuron, it get released into neuromuscular junction where it combine with a receptor molecule in the synaptic membrane of a muscle fibre.