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Discuss how axis formation occurs in amphibian development by answering each of the following questions. 1-...

Discuss how axis formation occurs in amphibian development by answering each of the following questions.

1- How does the convergence of multiple signal pathways due to the formation of the gray crescent lead to the formation of the primary organizer in Amphibians? Describe these pathways, the key molecules they effect, and how they lead to the primary organizer forming opposite the site of sperm entry.

2- What cellular events lead to the formation of different germ layers during gastrulation in amphibians. Discuss the role and function of superficial and deep cells, bottle cells, the blastocoel, the blastopore lip, the IMZ, the NIMZ, the archenteron, mediolateral intercalation, convergent extension, the yolk plug, and epiboly.

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