There are rare cases where a base substitution mutagen can revert a frameshift mutation if the...

There are rare cases where a base substitution mutagen can revert a frameshift mutation if the frameshift mutation is early in a DNA coding sequence. Suggest a mechanism by which this could occur.

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Ans.

The reversion of Frameshift mutations is known as revertant mosaicism.
This is a naturally occurring mechanism, in which the frameshift mutation is reverted due to a second mutation in another site that corrects the reading frame.
As this is a naturally occurring mechanism, it is known as "natural gene therapy".
Second-site mutation is the most probable mechanism through which the frameshift mutation is reverted.
This can occur either upstream or downstream of the frameshift mutation.
The second-site mutation is a spontaneous mutation and can occur in the introns.
This results in the restoration of the reading frame.
Reversion of frameshift mutation has been observed in many genetic disorders such as Bloom syndrome which is a rare genetic disorder that causes stunted growth, sensitive skin and dilation of blood vessels over nose and cheeks.
The reversion of frameshift mutations may also happen by other mechanisms such as mitotic gene conversion or DNA slippage.

gladiator answered 2 months ago

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