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In: Biology

BIOINFORMATICS (Python) In the following you are required to present on paper your solution to alignment...

BIOINFORMATICS (Python)

In the following you are required to present on paper your solution to alignment problems. Please use the Needleman-Wunsch algorithm to find the best global pairwise alignment and use the Smith-Waterman algorithm to find the best local pairwise alignment. For each (global or local) alignment you must: - Construct the dynamic programming matrix F(i,j) keeping track of the pointers Ptr(j,i). - Determine the score of the best pairwise alignment. - Present the best alignment. If there are more than one, present all the best.

PROBLEM 1

Consider the following two nucleotide sequences

Sequence 1: A A C G T T A C

Sequence 2: C G A T A A C

and the following scoring model:

Match = +1

Mismatch = -1

Gap = -1

PROBLEM 2

Consider the following two nucleotide sequences

Sequence 1: A C G C G T

Sequence 2: C G T A A

and the following scoring model:

Match = +5

Mismatch = -3

Gap = -4

Expert Solution

As required,Please find the attached final complete calculations of answer.

gladiator answered 2 years ago

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