Question

Inflammation and tumorigenesis are linked. Give 3 examples showing the linkage and why for each of those examples ?

Answer 1

Inflammation is biological response of body tissues to pathogens, damaged cells. It is a protective response that involve immune cells, blood vessels, molecular mediators.

Inflammation and tumorigenesis are linked and become evident that inflammatory response is an essential of tumors. Inflammatory responses play roles at different stages of tumor development.

Three examples showing the linkage are :

1) Chronic inflammation increases cancer risk.

As chronic inflammation cause DNA damage that leads to cancer. For instance, people with chronic inflammatory bowel diseases, for example ulcerative colitis and Crohn disease that have increased risk of colon cancer.

2) Obesity-induced inflammation increase cancer risk.

Obese people have chronic low-level inflammation that after some time cause DNA damage that cause cancer..

3) Signaling pathways mediate the protumorigenic effects of
inflammation

This is shown by an example, activation of NF-kB in immune cells induces cytokines that activates NF-kB in cancer cells and cause chemokines to attract more inflammatory cells into the tumor...