8. Large chromosome rearrangements or duplications are a common feature of cancers, but not of inherited...

8. Large chromosome rearrangements or duplications are a common feature of cancers, but not of inherited genetic traits.

8A. Explain why these types of mutations are not tolerated in live births. 4 pts)

8B. Explain why these types of mutations are common in cancers. (4 pts)

Expert Solution

8A. Large chromosome rearrangements or duplications generally lead to fatal consequences. This means that such rearrangements or duplications affect the normal functioning of the cells or the organism as a whole. They affect the fundamental metabolisms essential for survival of the organism. This also indicates that such modifications of the genetic traits are not in the gremline, thereby not possibly transferred from one generation to another. Even if such chromosome rearrangements or duplications are passed on as genetic traits from parents to offsprings, there is very little probability of the new-born's survival. Thus it can be concluded that these types of mutations are not tolerated in live births.

8B. Large chromosome rearrangements or duplications are mostly results of mutations due to external influences like prolonged exposure to powerful radiations, mutagens, UV effect, chemical exposure, etc. When there is undesired change or mutation in the chromosomes, it is evident that there will be severe undesired consequences which often lead to development of cancer. Most cancers are results of mutation that lead to uncontrolled cell growth and division. Thus, large chromosome rearrangements or duplications are a common feature of cancers.

gladiator answered 4 months ago

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