using the oxyhemoglobin dissociation curve describe the relationship between the O2 delivery cascade and arterial and...

using the oxyhemoglobin dissociation curve describe the relationship between the O2 delivery cascade and arterial and venous O2 content. Provide one (1) physiological reason that might lead to a reduction in arterial O2 content (CaO2) and one (1) reason there would be a decrease in venous O2 content (CvO2).

Expert Solution

Oxyhemoglobin Dissociation Curve- Relationship between the partial pressure of oxygen and the saturation of hemoglobin molecule. Mathematically equates the percentage saturation of hemoglobin to the partial pressure of oxygen in the blood.

curve uses O2 Sats and PaO2 to reflect the amount of oxygen available to the tissues.The upper-flat portion is lungs. The steep portion is tissues.Body can hold 96-97% down to 80 mm/Hg.

Changes in Affinity is caused by - pH, PaCO2, carbon monoxide, abnormal Hgb., temp, intracellular compounds, 2,3-DPG.

Oxygenated Hgb = stronger acid than deoxygenated Hgb. Change in pH facilitates the release of oxygen.

Changes in temperature - Decrease causes increased affinity, Shift to left. Increase causes decreased affinity, Shift to right. 2,3-Diphosphoglycerate (2,3-DPG) is the main primary organic phosphate.

An increase in 2,3-DPG shifts the curve to the right, whilst a decrease in 2,3-DPG shifts the curve to the left. 2,3-DPG binds to hemoglobin and rearranges it into the T state, which decreases its affinity for oxygen.

gladiator answered 2 years ago

What is the oxyhemoglobin dissociation curve, and what factors affect the curve to shift right or...

What is the oxyhemoglobin dissociation curve, and what factors affect the curve to shift right or left. Additionally, explain what type of effect stored (banked) blood have on the oxyhemoglobin dissociation curve. please use more than 350 words

How is partial pressure of a gas determined? What factors cause the oxyhemoglobin dissociation curve to...

How is partial pressure of a gas determined? What factors cause the oxyhemoglobin dissociation curve to shift downward and to the right to reflect enhanced unloading?

Topic 9: Oxygen-hemoglobin dissociation curve Define what the oxygen hemoglobin dissociation curve is and describe why...

Topic 9: Oxygen-hemoglobin dissociation curve Define what the oxygen hemoglobin dissociation curve is and describe why it is physiologically important. explain the significance of the sigmoidal shape, including the physiological significance of the plateau and step portions, and the relationship between oxygen loading/unloading with changes to po2 Give an example of a situation/condition that would result in a right shift of the oxygen hemoglobin dissociation curve. explain what causes the shift and relate it to oxygen binding affinity, loading-unloading of...

53-1/Acidic pH shifts the O2 -hemoglobin dissociation curve to the right. What will the result of...

53-1/Acidic pH shifts the O2 -hemoglobin dissociation curve to the right. What will the result of this shift be? Select one: _ a. More H+ will be unloaded in the pulmonary capillaries I b. Less H+ will bind to hemoglobin than O2 C. Less CO2 will be unloaded in the systemic capillaries d. More O2 will be unloaded in the systemic capillaries 2/Which of the following activates chymotrypsinogen in pancreatic juice? Select one: _ a. Enterokinase _ b. Trypsin C....

Explain the relationship between a patient’a O2 content and O2 saturation of hemoglobin?

Explain the oxygen dissociation curve and describe the significance of the flat portion and the steep...

Explain the oxygen dissociation curve and describe the significance of the flat portion and the steep portion of the curve.

Describe the difference between a "homolytic bond dissociation energy" and a "heterolytic bond dissociation energy". In...

Describe the difference between a "homolytic bond dissociation energy" and a "heterolytic bond dissociation energy". In most cases, for a given type of chemical bond, the homolytic bond dissociation energy is less than the heterolytic bond dissociation energy. Explain.

a) Explain the relationship between unemployment and inflation using the concept of Philips curve. What are...

a) Explain the relationship between unemployment and inflation using the concept of Philips curve. What are the critics on Philips Curve? b) Use the Phillips Curve to explain policy responses to a supply shock caused by increase in the world price of oil c) Discuss Walras's Law statement that the sum of the nominal excess demands for all goods in the economy must be zero.

How does the difference between arterial and venous O2 content change during exercise compared to rest?...

How does the difference between arterial and venous O2 content change during exercise compared to rest? What causes this change in the arterial-venous oxygen difference?

What is the relationship between the MPL curve and the total product curve?

Question