using the oxyhemoglobin dissociation curve describe the relationship between the O2 delivery cascade and arterial and...

using the oxyhemoglobin dissociation curve describe the relationship between the O2 delivery cascade and arterial and venous O2 content. Provide one (1) physiological reason that might lead to a reduction in arterial O2 content (CaO2) and one (1) reason there would be a decrease in venous O2 content (CvO2).

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Expert Solution

Oxyhemoglobin Dissociation Curve- Relationship between the partial pressure of oxygen and the saturation of hemoglobin molecule. Mathematically equates the percentage saturation of hemoglobin to the partial pressure of oxygen in the blood.

curve uses O2 Sats and PaO2 to reflect the amount of oxygen available to the tissues.The upper-flat portion is lungs. The steep portion is tissues.Body can hold 96-97% down to 80 mm/Hg.

Changes in Affinity is caused by - pH, PaCO2, carbon monoxide, abnormal Hgb., temp, intracellular compounds, 2,3-DPG.

Oxygenated Hgb = stronger acid than deoxygenated Hgb. Change in pH facilitates the release of oxygen.

Changes in temperature - Decrease causes increased affinity, Shift to left. Increase causes decreased affinity, Shift to right. 2,3-Diphosphoglycerate (2,3-DPG) is the main primary organic phosphate.

An increase in 2,3-DPG shifts the curve to the right, whilst a decrease in 2,3-DPG shifts the curve to the left. 2,3-DPG binds to hemoglobin and rearranges it into the T state, which decreases its affinity for oxygen.

gladiator answered 1 year ago

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