1. Compute for the A + C : T + G ratios of the given DNA...

1. Compute for the A + C : T + G ratios of the given DNA strand in "A"

5' A A C C T A C T C C T G C G T G G G T G T C T T 3'

3' T T G G A T G A G G A C G C A C C C A C A G A A 5'

2. What happens if any of the protein for initiation of replication was not synthesized by the cell? Explain briefly why

Expert Solution

1 No of Adenine = 3

No of cytosine = 7

A+C= 10

No of guanine=6

no pf thymine= 8

T+G= 14

so A+C/T+G = 10/14= 0.714

2. The DNA replication is coupled with the cell cycle for the cell to function properly. So if there is a hault or incomplete DNA replication the cell will undergo death i.e apoptosis. The replication is regulated via proteins that are required for the initiation to form the origin of replication and the cyclin dependent kinases move cell cycle from G1-S-G2 phase. The oriC is activated with the help of protein complex in the G1 phase (pre-replicative complex) which contains the origin of recognition complex and other protein Cdc6, these are required for the initiation of the replication process.With the cell unable to produce these proteins, the origin of replication is deactivated which results in the inability to form replication fork. So the DNA cannot replicate and the chromosomes do not double in number which means after mitosis when the daughter split up each would get only half the chromosomes. This uncoupling of DNA replication from the cell cycle contribute to cell death by induction of DNA damage.

gladiator answered 1 year ago

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