Question

DIscuss Alberch’s experiments on limb development in Ambystoma mexicanum, epigenetic processes, and saltation in morphological evolution.

Answer 1

Alberch blended many comparative and experimental methodologies that has an importance for development of evolutionary trends, By approaching many analyses the limb development continue to provide different fundamental insights, The signals that coordinate the specification and determination of classical patterning with proliferation and survival that underlying the interactions which can define the self-regulatory and as well as robust signalling systems that interlink and can connect the multiple pathways. The limb in ambystoma mexicanum is helpful to compare the behavior of amphibian and chick limbs, some of the limb have paradigmatic values so that we can understand the vertebrate organogenesis. Transplantation and rotation of limb helps to reverse the dorso-ventral, antero-posterior nor both axes that can result in the induction of the supernumerary limbs in many cases. In recent times by genetic analysis towards mice has revealed the existence of many self-regulatory limb signaling system that can involves many of the pathways which can be helpful in the regulatory morphogenesis. The development of limb can helpful in the knowledge of the signalling interactions that can govern the limb skeletal development into a new systems model that results an integrative model and can be provide the  insights of specification.