Is toulene or benzene more toxic to humans?

Expert Solution

Ans. The answer depends on the “context of toxicity”.

I. Toluene exhibits higher acute toxicity than benzene: LD₅₀ for toluene is 636 mg/ kg whereas that of benzene is 930 mg /kg. The acute toxicities of toluene are more intense than that of benzene.

Ref: https://books.google.co.in/books?id=e4_S46UcI2AC&pg=PT329&lpg=PT329&dq=Is+toluene+or+benzene+more+toxic+to+humans&source=bl&ots=oxC1oGDcZH&sig=HIOuWTu80yuugVHOGtOaQR55KfE&hl=en&sa=X&ved=0ahUKEwjwy_HEsujXAhWINI8KHVp8DtYQ6AEISTAF#v=onepage&q=Is%20toluene%20or%20benzene%20more%20toxic%20to%20humans&f=false

II. Benzene is carcinogenic: The carcinogenic effects of benzene are well established. The toluene does not exhibit carcinogenic effects in long-term exposure. The products of benzene metabolism (benzoxide, epoxides, etc.) may react with DNA and cause genotoxicity. Moreover, these products are retained in the body for prolonged period as their excretion is not readily facilitated due to their relatively greater hydrophobic nature.

The products of toluene metabolism (benzoic acid, cresols, etc.) are more hydrophobic and are readily excreted when compared to that of the products of benzene metabolisms. Moreover, the carcinogenic effects of toluene are still not well established.

Therefore, when chronic exposure is considered, benzene is more toxic than benzene.

queen_honey_blossom answered 2 years ago

Is toulene or benzene more toxic to humans?

Exposure to toxic materials can be hazardous to humans. What variables affect the amount of toxic...

Exposure to toxic materials can be hazardous to humans. What variables affect the amount of toxic material an organism will be exposed to? What effect do these variables have?

All humans share some fundamental characteristics inherited from their Australopithecus ancestors. But humans share more characteristics...

All humans share some fundamental characteristics inherited from their Australopithecus ancestors. But humans share more characteristics than what was listed on those slides – characteristics also shared with most animals. One of these is the cell membrane protein ACE-2. ACE-2 is a highly conserved protein, meaning that mutations in the ACE-2 gene are rare. Studies of how these rare mutations are distributed across the human world population are still in early stages (Cao et al. 2020). However, four things are...

It has been estimated that in humans, there are more than _________ hormones present in the...

It has been estimated that in humans, there are more than _________ hormones present in the body. 15 1000 150 80 Which of the following statements best describes the role of hormones within the human body. All hormones elicit the same effect on the same tissue and the effects only last a few minutes. Each hormone only works on specific cell types in specific tissues and the effects can last from a few minutes to years. All hormones elicit the...

For non-carcinogenic effects which of the two chemicals (for the same dose) is more toxic and...

For non-carcinogenic effects which of the two chemicals (for the same dose) is more toxic and why? a) Chlorine b) Chloroform

1. Why are aminoglycosides more selectively toxic to bacteria than human cells? (Be sure to be...

1. Why are aminoglycosides more selectively toxic to bacteria than human cells? (Be sure to be complete and specific in your answer to make it clear why these drugs are more toxic to bacterial cells than to human cells.) 2. Penicillins and cephalosporins are beta-lactam antibiotics. Plasmids coding for beta-lactamase enzymes make the bacterium resistant to these antibiotics. What do beta-lactamases do? 3. The malarial organism possesses the remnants of a chloroplast, called an apicoplast. How does tetracycline inhibit growth...

1. When environmental pollutants degrade, they may become more toxic than the original pollutant that was...

1. When environmental pollutants degrade, they may become more toxic than the original pollutant that was emitted. True False

As humans, we keep track of large amounts of information more efficiently by putting it into...

As humans, we keep track of large amounts of information more efficiently by putting it into categories. One example of this is to organize the organs of the human body into organ systems – you have 11 listed in chapter 5 of your textbook. Organizing the body in this way is useful but can cause us to view each organ system individually when, in fact, organ systems work together in many ways. Make a convincing argument for viewing the organ...

Imagine that humans will someday evolve to have brains that are more resilient to Traumatic Brain...

Imagine that humans will someday evolve to have brains that are more resilient to Traumatic Brain Injuries (TBI) than those we have today. What anatomically and/or cellular changes might need to occur in the human brain for it to confer this resilience?

Carleton Chemical claims that they can produce more than 800 tons of benzene on average per...

Carleton Chemical claims that they can produce more than 800 tons of benzene on average per week. A random sample of 36 weeks of production yields a mean and SD as follows: x ̅=823 and s = 79.8. At the = .05 significance level, does the sample data provide significant evidence to support the claim made by the Carleton Company? a) Set up hypotheses Ho and Ha to test the company’s claim. Go to STAT >> TESTS, and choose T-test...

Question

Is toulene or benzene more toxic to humans?

Solutions

Expert Solution

Related Solutions

Is toulene or benzene more toxic to humans?

Exposure to toxic materials can be hazardous to humans. What variables affect the amount of toxic...

All humans share some fundamental characteristics inherited from their Australopithecus ancestors. But humans share more characteristics...

It has been estimated that in humans, there are more than _________ hormones present in the...

For non-carcinogenic effects which of the two chemicals (for the same dose) is more toxic and...

1. Why are aminoglycosides more selectively toxic to bacteria than human cells? (Be sure to be...

1. When environmental pollutants degrade, they may become more toxic than the original pollutant that was...

As humans, we keep track of large amounts of information more efficiently by putting it into...

Imagine that humans will someday evolve to have brains that are more resilient to Traumatic Brain...

Carleton Chemical claims that they can produce more than 800 tons of benzene on average per...