Question

1. How does cyanide poisoning relate to respiration? limit to 1 paragraph

Answer 1

cellular respiration involves the oxidation of glucose via glycolysis, preparatory reaction, TCA cycle, and electron transport chain. glycolysis, preparatory reaction, TCA cycle produces NADH and TCA cycle produces FADH2, these reduced coenzymes are oxidized by the electron transport chain, there are four different complexes in the inner mitochondrial membrane, complex I, complex III, and complex IV are redox pumps, complex I oxidizes NADH and transfers the electrons to ubiquinone which transfers electrons to complex III  and complex II oxidised FADH2and transfers the electrons to ubiquinone which transfers electrons to complex III. from complex III electrons are carried by cytochrome c to complex IV. Cyanide inhibits the complex IV, which transfers the electrons to the oxygen. when the complex IV is inhibited electrons transport stops so NADH and FADH2 accumulate in the cell, NAD+ is required for the glycolysis, preparatory reaction and TCA cycle to occur, since NADH and FADH2 are not oxidized the cell cannot carry out glycolysis, preparatory reaction and TCA cycle to obtain energy so the cell dies.