In: Biology
23) There are thousands of promoters in the prokaryotic genome. Outline the mechanism used prokaryotic mRNA polymerase navigate to the right promoter to address a particular cellular need.
There are thousands of promoter in prokaryotic genome. The mechanism used prokaryotic mRNA polymerase navigate the right promoter to address a particular need sigma factor.
Initiation of transcription can only occurs from promoter region of DNA, an initiation factor Sigma binds to the core enzyme and is called holoenzyme (RNA pol+ sigma factor). The specific sigma factor used to initiate transcription of a given gene will vary, depending on the gene and on the environmental signals needed to initiate transcription of that gene. Selection of promoters by RNA polymerase is dependent on the sigma factor that associates with it. The detail function and work of RNA polymerase and sigma factor is explained in the images, please go through it: for any further queries, do comments. Thank you.