Question

Ion channels have exquisite specificity and can selectively open or close. The opening and closing is a process known as gating. Distinguish Mechanoselective channels.

Answer 1

Mechanoslective channels are active and located in the stereocilia of the inner ear. Their selectivity vary in permeating ions from non selective between anions and cations, driven by conductive forces. They play a role in open in response as a physical distortions of the cell membrane, as well as alter the membrane comformation between an open and close state during mechanical deformations for example, machanoselective calcium channel in plasma membrane, whih can be amplified through release of internal pores especially from vacoule like through two pore channel to maintain membrane integrity and ion homeostasis.

Many channels associated with the sense of touch are mechanically gated. For example, as pressure is applied to the skin, these channels open and allow ions to enter the cell. Similar to this type of channel would be the channel that opens in the basis of temperature changes, as in testing the water in the shower. When a mechanical change occurs in the surrounding tissue, such as pressure or touch, the channel is physically opened. Thermoreceptors work on a similar principle. When the local tissue temperature changes, the protein reacts by physically opening the channel.