Proto-oncogenes are normal growth-promoting genes that can be activated to their oncogenic form. Discuss with emphasis...

Proto-oncogenes are normal growth-promoting genes that can be activated to their oncogenic form. Discuss with emphasis on the four major mechanism of oncogenic activation. (Min 2 and a half pages)

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gladiator answered 2 years ago

Cancer is a genetic disease that arises due mutations in growth promoting genes (oncogenes) and in...

Cancer is a genetic disease that arises due mutations in growth promoting genes (oncogenes) and in growth suppressing genes (tumor suppressor genes). Mutations in oncogenes that can lead to cancer are gain-of-function mutations that result in the constitutive activation of the proteins encoded by these genes. An example of such a gene is Ras, a gene mutated in over 90% of pancreatic cancers. When mutated, the Ras signaling is constitutively active, leading to uncontrolled cell growth. Tumor suppressor genes encode...

Describe the role of proto-oncogenes/oncogenes OR tumor suppressor genes in the development of cancer. RNA processing...

Describe the role of proto-oncogenes/oncogenes OR tumor suppressor genes in the development of cancer. RNA processing splices introns out of pre-mRNA producing mature mRNA. Describe what happens when some genes undergo alternative splicing.

List three different types of retrovirus-encoded oncogenes that are represented by proto-oncogenes in normal cells. Briefly...

List three different types of retrovirus-encoded oncogenes that are represented by proto-oncogenes in normal cells. Briefly describe the general function of the viral oncogene or its corresponding proto-oncogene.

The genes that encode BRCA1 and ATM proteins are proto-oncogenes/tumor suppressors (highlight one of the two...

The genes that encode BRCA1 and ATM proteins are proto-oncogenes/tumor suppressors (highlight one of the two preceding terms). Justify your choice in 1-3 sentences by describing the functions of these proteins. Justification:

Which of the following is the best description of a proto-oncogene? A. A normal important growth-regulating...

Which of the following is the best description of a proto-oncogene? A. A normal important growth-regulating gene B. A gene that codes for a catabolite activator protein C. A specific gene sequence that is observed in lower animals but that produces pseudogenes in humans D. Any gene that produces an oncogenic effect Why B and C not correct answer?

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Proto-oncogenes are normal growth-promoting genes that can be activated to their oncogenic form. Discuss with emphasis...

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