Proto-oncogenes are normal growth-promoting genes that can be activated to their oncogenic form. Discuss with emphasis...

Proto-oncogenes are normal growth-promoting genes that can be activated to their oncogenic form. Discuss with emphasis on the four major mechanism of oncogenic activation. (Min 2 and a half pages)

Expert Solution

gladiator answered 3 years ago

Cancer is a genetic disease that arises due mutations in growth promoting genes (oncogenes) and in...

Cancer is a genetic disease that arises due mutations in growth promoting genes (oncogenes) and in growth suppressing genes (tumor suppressor genes). Mutations in oncogenes that can lead to cancer are gain-of-function mutations that result in the constitutive activation of the proteins encoded by these genes. An example of such a gene is Ras, a gene mutated in over 90% of pancreatic cancers. When mutated, the Ras signaling is constitutively active, leading to uncontrolled cell growth. Tumor suppressor genes encode...

Describe the role of proto-oncogenes/oncogenes OR tumor suppressor genes in the development of cancer. RNA processing...

Describe the role of proto-oncogenes/oncogenes OR tumor suppressor genes in the development of cancer. RNA processing splices introns out of pre-mRNA producing mature mRNA. Describe what happens when some genes undergo alternative splicing.

List three different types of retrovirus-encoded oncogenes that are represented by proto-oncogenes in normal cells. Briefly...

List three different types of retrovirus-encoded oncogenes that are represented by proto-oncogenes in normal cells. Briefly describe the general function of the viral oncogene or its corresponding proto-oncogene.

The genes that encode BRCA1 and ATM proteins are proto-oncogenes/tumor suppressors (highlight one of the two...

The genes that encode BRCA1 and ATM proteins are proto-oncogenes/tumor suppressors (highlight one of the two preceding terms). Justify your choice in 1-3 sentences by describing the functions of these proteins. Justification:

Which of the following is the best description of a proto-oncogene? A. A normal important growth-regulating...

Which of the following is the best description of a proto-oncogene? A. A normal important growth-regulating gene B. A gene that codes for a catabolite activator protein C. A specific gene sequence that is observed in lower animals but that produces pseudogenes in humans D. Any gene that produces an oncogenic effect Why B and C not correct answer?

discuss the role of government policy in promoting or retarding economic growth in one of the...

discuss the role of government policy in promoting or retarding economic growth in one of the following “development states” of east or south-east Asia: South Korea, Indonesia, Malaysia

Discuss how fusion genes can originate from chromosomal breaks, and how these fusion genes can lead...

Discuss how fusion genes can originate from chromosomal breaks, and how these fusion genes can lead to cancer?

Provide two examples of how therapeutic genes can be delivered into cells, and discuss the challenges...

Provide two examples of how therapeutic genes can be delivered into cells, and discuss the challenges scientists face in making gene therapy an effective technique for treating human genetic disease conditions. basic biotechnology

The p53 protein can activate genes involved in apoptosis, known as programmed cell death. Discuss how...

The p53 protein can activate genes involved in apoptosis, known as programmed cell death. Discuss how mutations in genes coding for proteins that function in apoptosis could contribute to cancer.

Answer in detail please, high percentage of my grade 1) Discuss how fusion genes can originate...

Answer in detail please, high percentage of my grade 1) Discuss how fusion genes can originate from chromosomal breaks, and how these fusion genes can lead to cancer b) Within your answer, please discuss in detail the genotype, and how this leads to the phenotype of at least one type of cancer c) discuss the genetic screening techniques that can be used to assess this disorder, and any recent developments in this area d) discuss how a detailed understanding of...

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