Question

What is the main goal of GWAS? 

• Identify autosomal locations where recombination happens the most frequently 

• Identify which single nucleotide polymorphisms are most representative of worldwide variation 

• Identify disease loci by comparing the genotypes of closely related family members 

• Identify genomic locations where genetic variation contributes to phenotypic variation

Answer 1

• Identify which single nucleotide polymorphism are most representative of worldwide variation.

GWAS (Genome wide association study) focus on genome wide genetic variants in different person or individual of the world to analyze any variant associated with which trait and also focus on the association between traits and SNP(single nucleotide polymorphism). Trait may be any human disease and applicable on other organisms and genetic variant.

For example: DNA samples are taken from individuals having disease and then genetic variants reading are taken using single nucleotide polymorphism. If one type of allele or variant is found more in people which are having disease then we can say that this variant is closely associated with disease. And SNPs can be marked as a region that may influence disease.