Question

What hormone RECEPTOR is found in the membrane of both an ovarian follicular cell and a testicular Sertoli cell and from where does this hormone originate?

one-two sentence answers, please.

Answer 1

Granulosa cells of follicles in ovaries and Sertoli cells in testis express the follicle stimulating hormone receptor (FSH) on their surface which binds to follicle stimulating hormone (FSH). FSH hormone that is secreted by the anterior pituitary in response to the gonadotropin-releasing hormone (GnRH) secreted by the hypothalamus in brain.

Explanation for reference:

FSH is expressed and secreted by anterior pituitary in response to pulsatile GnRH secreted by the hypothalamus in both females and males. In females, the ovum is present in ovarian follicles and is released during ovulation. Ovarian follicle has granulosa cells that surround the ovum. Granulosa cells are surrounded by theca cells. Granulosa cells express FSH receptors that bind to pituitary FSH. This binding induces a signaling cascade that leads to production of estrogen that causes endometrial cell proliferation in the uterus. The thecal cells express luteinizing hormone (LH) receptors which bind LH and induce production of progesterone. Theca cells form the corpus luteum after ovulation.

Sertoli cells and Leydig cells are present in the testis and are involved in spermatogenesis. Sertoli cells express FSHR while Leydig cells express LHR. Sertoli cells are nurse cells that respond to FSH. They provide an immunological protective barrier to germ cells. Sertoli cell express androgen binding protein, inhibin and anti-Mullerian hormone. Androgen binding protein is required for transport of testosterone to germ cells for spermatogenesis. Leydig cells respond to LH and induce testosterone secretion.