Question

In: Anatomy and Physiology

what are two different categories of ion channels found at the neuromuscular junctio

what are two different categories of ion channels found at the neuromuscular junctio

Solutions

Expert Solution

Neuromuscular Junction is the junction between A Nerve Fibre and a muscle fibre.It contains-

a.Pre synaptic membrane:Membrane of nerve Fibre

b.Synaptic Cleft:A gap between Nerve fibre and muscle fibre.

c.Post synaptic membrane:Membrane of muscle fibre.

The 2 Important Ion channels in the Neuromuscular junction are-

a.Voltage Gated Calcium channels:

*Voltage Gated Calcium channels are found in the presynaptic membrane.

*When action potential reaches Presynaptic axon terminal--Axon terminal Depolarisation occur-----This causes Opening of voltage gated Ca2+ channels---This calcium binds to Synaptic vesicles--this Causes fusion of Synaptic vesicle with pre synaptic Membrane ---which results in the Release of Neurotansmitter(Acetyl CHoline) into Synaptic Cleft.

b.Voltage gated Na+ channels:

When Neurotransmitter which is released into Synaptic cleft binds to its receptor in the post synaptic membrane--Some positive Ions enter post synaptic Membrane---This cuases Opening of Voltage gated Na+ channels--Rapid Na+ iNfulx causing depolarisation of Post synaptic membrane.


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