what are two different categories of ion channels found at the neuromuscular junctio

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Expert Solution

Neuromuscular Junction is the junction between A Nerve Fibre and a muscle fibre.It contains-

a.Pre synaptic membrane:Membrane of nerve Fibre

b.Synaptic Cleft:A gap between Nerve fibre and muscle fibre.

c.Post synaptic membrane:Membrane of muscle fibre.

The 2 Important Ion channels in the Neuromuscular junction are-

a.Voltage Gated Calcium channels:

*Voltage Gated Calcium channels are found in the presynaptic membrane.

*When action potential reaches Presynaptic axon terminal--Axon terminal Depolarisation occur-----This causes Opening of voltage gated Ca2+ channels---This calcium binds to Synaptic vesicles--this Causes fusion of Synaptic vesicle with pre synaptic Membrane ---which results in the Release of Neurotansmitter(Acetyl CHoline) into Synaptic Cleft.

b.Voltage gated Na+ channels:

When Neurotransmitter which is released into Synaptic cleft binds to its receptor in the post synaptic membrane--Some positive Ions enter post synaptic Membrane---This cuases Opening of Voltage gated Na+ channels--Rapid Na+ iNfulx causing depolarisation of Post synaptic membrane.

Sydney Mullin answered 8 months ago

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