In: Anatomy and Physiology
GROWTH HORMONE EXCESS
Growth hormone is secreted by the anterior pituitary gland and is regulated by the hypothalamus by the production of growth hormone regulating hormone. It is important for growth and metabolism.
Excessive growth hormone production occurs in pituitary tumors. Excessive growth hormone in children is called gigantism and in adults it is called acromegaly. The effect of growth hormone is mediated via increased levels of insulin-like growth factor-1 (IGF 1).
Gigantism
Symptoms of gigantism include accelerated linear growth, muscle weakness, headache, insomnia.
Muscle weakness causes restricted movement and some of them also have psychological problems.
Acromegaly
Symptoms of acromegaly include increase in size of bones - including hands,feet and face, excessive sweating, muscle weakness.
Untreated cases can develop Type 2 Diabetes, and Cardiovascular problems causing morbidity.