Question

40. Genetic variation associated with CYP2C19 metabolism confers which of the following phentotype?

A. Polymorphic alleles

B. Heterozygosity

C. Poor metabolizer

D.Slow Acetylator

Answer 1

Genetic variation in a difference in the DNA sequence in each genome of the organism causing evolution which may have good or bad impact on the body.

Phenotype is an observation train which are associated with genotype.

Genetic variation associated with CYP2C19 metabolism confers which of the following phenotype?

A. Polymorphic alleles- is a one or more alleles mutation of the DNA sequence in the genome leads to change in genotype. Leads to discontinues alleles or genotype.

B. Heterozygosity-is a inheritance of different form of gene from the parents. It is related to genotype.

C. Poor metabolizer is a condition in which patient having slow breakdown of medicine and pronounced side effect of drug. Poor metabolizer phenotype occurs when the both genotype either CYP2C19 or CYP2D6 have genetic variation leads to inactivation of enzymes.

D.Slow Acetylator phenotype is a autosomal recessive trait and interacted with NAT2 genotype.

Hence option c is a correct answer.

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