Multiple Sclerosis (MS) is an Autoimmune disease that is very difficult to diagnose. Using M13 library,...

Multiple Sclerosis (MS) is an Autoimmune disease that is very difficult to diagnose. Using M13 library, how can you develop a diagnostic tool to differentiate MS from other diseases with similar symptoms. In details, start with:

a. What type of peptide will you use? Where will you insert the peptide? And how will you construct the M13 vector to make the library?

b. How will you make the M13 itself?

c. How will you develop and test the assay?

d. Once you have isolated the M13 specific to MS, in general, how will you identify the sequence from M13?

Solutions

Expert Solution

gladiator answered 9 months ago

Next > < Previous

Related Solutions

4. Multiple sclerosis (MS) is an autoimmune disease in which self-reactive T cells and antibodies attack...

4. Multiple sclerosis (MS) is an autoimmune disease in which self-reactive T cells and antibodies attack neurological tissues in the brain. This disease is associated with HLA-DR2 and is ten times more frequent in women than in men. What type of molecule does the HLA-DR2 gene code for? What does it mean that MS is associated with HLA-DR2? Specifically, is this a causal relationship? What does it mean that MS is more frequent in women than in men? d. In...

Multiple sclerosis (MS) is an autoimmune disorder in which the immune system destroys myelin sheaths surrounding...

Multiple sclerosis (MS) is an autoimmune disorder in which the immune system destroys myelin sheaths surrounding axons. Which aspect of nerve transmission would be most affected by MS? signal termination continuous conduction generator potentials saltatory conduction

In your opinion, which disease is more difficult in diagnosis and management (Multiple sclerosis or Myasthenia...

In your opinion, which disease is more difficult in diagnosis and management (Multiple sclerosis or Myasthenia gravis) and why? . What is the prognosis for each disease? Nursing intervention that should be considered

Case Study: Ms. Tuckerno has been diagnosed with multiple sclerosis (MS). The patient receives care at...

Case Study: Ms. Tuckerno has been diagnosed with multiple sclerosis (MS). The patient receives care at an internal medicine clinic. Her internist is not in the office today and she is being treated by the nurse practitioner. The patient is on two medications for her MS, three different blood pressure medications, one medication for thyroid disease, one diabetic pill daily, insulin injections twice a day, she uses medical cannabis, and uses eye drops for glaucoma. Upon assessing the patient, the...

Case Study: Ms. Tuckerno has been diagnosed with multiple sclerosis (MS). The patient receives care at...

Multiple sclerosis is a type of disease where myelin sheath of nerve cells in the brain...

Multiple sclerosis is a type of disease where myelin sheath of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, and trouble with sensation or coordination. If Nerve a is a neuron in Patient A’s and nerve B...

1. Multiple Sclerosis (MS) (a) Provide an understanding of how the physiological process axon demyelination relates...

1. Multiple Sclerosis (MS) (a) Provide an understanding of how the physiological process axon demyelination relates to the symptoms of MS. (b) Draw a diagram or provide a table showing the physiological differences (resting membrane potential value, ability to produce action potentials (AP), AP threshold, AP propagation, AP peak and AP duration) between MS patients and typical individuals. (c) How does temperature alter action potential generation? Investigate the effect of temperature in alleviating the symptoms of MS in MS patients....

Visceral leishmaniasis has a very high case fatality rate but is difficult to diagnose: bone marrow...

Visceral leishmaniasis has a very high case fatality rate but is difficult to diagnose: bone marrow biopsy, one of the best diagnostic methods, is expensive and is often associated with serious side effects. If you were developing a new diagnostic for this disease, would you be more interested in maximizing sensitivity or specificity? Also, assuming your new test is cheaper and less invasive than biopsy, would you advocate that it be used in conjunction with (ie simultaneously) or prior to...

Mr. U has been diagnosed as having multiple sclerosis (MS). As part of his treatment, he...

Mr. U has been diagnosed as having multiple sclerosis (MS). As part of his treatment, he is given baclofen (Lioresal) for muscle spasticity. As a nursing student, he is your assigned patient for the morning. Your clinical instructor has informed you that Mr. U has many questions about the use of baclofen for the treatment of spasticity. How will you best answer the following questions? How does baclofen work? What are the side effects of this drug? What precautions will...

A 64-year-old woman with multiple sclerosis (MS) is hospitalized. The team feels she may need to...

A 64-year-old woman with multiple sclerosis (MS) is hospitalized. The team feels she may need to be placed on a feeding tube soon to assure adequate nourishment. They ask the patient about this in the morning and she agrees. However, in the evening (before the tube has been placed), the patient becomes disoriented and seems confused about her decision to have the feeding tube placed. She tells the team she doesn’t want it in. They revisit the question in the...

Subjects