explain the core technology behind microarrays? (please box the answer)

explain the core technology behind microarrays?

(please box the answer)

Expert Solution

DNA Microarray technology has made it possible to produce and analyze data measuring the levels of mRNA from thousands of genes in a single experiment

The core concept in CGH is the use of genomic DNA (gDNA) in the hybridization to compare the gDNA from a disease sample versus that of a healthy individual. Hence, a typical microarray design can be used in this approach.

Each chip consists of short, single stranded pieces of DNA called oligonucleotides affixed to a glass slide. Because a single chip contains thousands of spots, each experiment can accurately analyze the expression levels of thousands of genes;
Databases allow scientists around the world to access and share large amounts of data during their genomic studies;
Microarrays and their resulting analyses have already contributed significantly to specific discovery. Expression analysis is presently used in drug development, drug response studies, and therapeutic development.

gladiator answered 2 years ago

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