Question

explain the core technology behind microarrays?

(please box the answer)

Answer 1

DNA Microarray technology has made it possible to produce and analyze data measuring the levels of mRNA from thousands of genes in a single experiment

The core concept in CGH is the use of genomic DNA (gDNA) in the hybridization to compare the gDNA from a disease sample versus that of a healthy individual. Hence, a typical microarray design can be used in this approach.

Each chip consists of short, single stranded pieces of DNA called oligonucleotides affixed to a glass slide. Because a single chip contains thousands of spots, each experiment can accurately analyze the expression levels of thousands of genes;
Databases allow scientists around the world to access and share large amounts of data during their genomic studies;
Microarrays and their resulting analyses have already contributed significantly to specific discovery. Expression analysis is presently used in drug development, drug response studies, and therapeutic development.