Question

Complete the following chart coagulation proteins.

Factor Number	Roman Numeral	Name (s)	Pathway (intrinsic, extrinsic or common)	Vit. K Necessary for Production Yes or No
1
2
3
5
7
8
9
10
11
12
13

Answer 1

Coagulation is the process of the formation of blood clots. Proteins that help in coagulation is called clotting factors, present in the blood. There are 13 clotting factors that are synthesized in the liver. To produce certain clotting factors body liver require vitamin k as coenzyme those factors are factors II, VII, IX, and X. Coagulation occurs in 3 pathways. Intrinsic pathway, extrinsic pathway, and common pathway.

Intrinsic pathway: It is activated by injury in the vascular system. It requires clotting factors IV, VII, IX, X, XI, and XII. After activation of all these factors, intrinsic pathway enters the common pathway

Extrinsic pathway: In this pathway, the clotting factors VII, III, And X are involved. after activation of all these factors, this enter to the common pathway

Common pathway: Here final blood clot is formed. Clotting factors involved are X, V, IV, II, I, and XIII

Factor number	Roman Numeral	Name (s)	Pathways (intrinsic, extrinsic or common)	Vit. K necessary for the production? Yes or No
1	I	fibrinogen	Common	No
2	II	prothrombin	Common	Yes
3	III	tissue factor (tissue thromboplastin)	Extrinsic	No
4	IV	Calcium ion	Intrinsic, Common	No
5	V	labile factor (proaccelerin)	Common	No
6	VI	absent		NO
7	VII	stable factor (proconvertin)	Extrinsic	Yes
8	VIII	antihemophilic factor	Intrinsic	No
9	IX	Christmas factor (plasma thromboplastin component-PTC)	Intrinsic	Yes
10	X	Stuart-Prower factor	Intrinsic, Extrinsic, Common,	Yes
11	XI	plasma thromboplastin antecedent	Intrinsic	No
12	XII	Hageman factor	Intrinsic	No
13	XIII	fibrin-stabilizing factor	Common	No