Describe the steps of excitation-contraction coupling and the role of calcium in this process.

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Expert Solution

The physiological process by which an electrical stimulus is converted to a mechanical response is called as excitation-contraction coupling.The following are the steps of excitation-contraction coupling are:

The Action Potential travels to the T-tubules via sarcolemma.
The Calcium gets released into the S.R. (sarcoplasmic reticulum).
The action of the tropomysoin which is blocking in nature gets removed as soon as the calium binds to actin.
The beginning of contraction is marked by the myosin heads being attached.
Then the removal of Calcium is done and the blocking of binding sites on actin happens again which is done by tropomyosin.
The last step relaxes the muscles.

Role of Calcium:

Basically, at first the Calcium concentration increases transiently in the myoplasm. This results in trigerring the mechanochemical reaction which is contraction.This increase is termed as Ca transient. The release takes place from sarcoplasmic reticulum.

Next, the Calcium acts as a very effective agonist which opens the Calcium channels of SR.

Sydney Mullin answered 9 months ago

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