In: Anatomy and Physiology
Anissa is working in an electrophysiology lab. She has isolated an excitable patch of membrane in the cell, generates one action potential but then finds that she cannot generate any action potentials, even with the supre-threshold stimulation. Which of the following statements could most likely account for this scenario?
a) The cell Anissa is recording does not contain voltage gated
Na+ channels
b) The intracellular concentration of K+ ions is now higher than
the extracellular concentration
c) The membrane contains voltage gated K+ channels that produce
after-hyperpolarizations
d) The voltage gated Na+ channels in the membrane are all
permanently inactivated
d) The voltage gated Na+ channels in the membrane are all permanently inactivated.
Hence, we can say voltage gated Na+ channels in the membrane are all permanently inactivated so that no impulses are able to generate action potential.