Question

Males and females possess the same gene for Follicle-Stimulating Hormone, which is a glycoprotein. Therefore, the tertiary structure of FSH is not different between men and women. Yet when FSH is injected into a male or a female, the physiological effects are different. Which cells in males and females are responsive to FSH and how does the body determine which cells will respond to which hormones? Focus on what’s happening at the cellular level as well as at the systemic level, contrasting between male and female. Furthermore, relating to the notion of injecting FSH directly into a patient, what problems (both endocrine and reproductive) would be caused by doing this repeatedly, and what would be the physiological reasons behind these problems?

Answer 1

In women FSH ( follicle Stimulating hormone) it mainly acts on endomtrium.

FSH promotes the development of ovarian follicles.

Also increases the secretion of oestradiol.

Whereas in males FSH and androgens combinely maintain the gametogenic functions of the testis.

Less androgen is required if FSH is present for spermatogenesis.

Though both in males and females have the same structure of FSH, due to physiological difference FSH predominantly acts on the endometrium.

And probably due to high androgens in males causes the negative feedback control mechanism to FSH production.

However if FSH is injected in females, it causes the superovulation . It widely used in women who failed to get pregnancy.

In males FSH injection promotes the spermatogenesis and also promotes the growth of semeniferous tubules.

FSH being a glycoprotein bind to surface receptors. It acts through secondary messengers namely cAMP .

In short in females it acts on endometrium

In males it acts on the semeniferous tubules.

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