In: Biology
The patient is a 7 year old male who has an abdominal mass. The mass involves his small bowel, and biopsy reveals a high grade tumor with starry sky pattern, small cells with high mitotic count and high apoptotic rate. Flow cytometry shows a population of cells expressing CD19, CD20 and CD10. FISH is positive for t(8;14).
What is the name of the abnormal gene?
The peripheral blood has large blasts with basophilic vacuolated
cytoplasm and irregular nuclei. The blasts have the same
immunophenoptype as the small bowel tumor. What is your
diagnosis?