Question

I keep getting more confused about GABA inhibitor the more I read about it through the chapters, can you explain it to me clearly?

Answer 1

DON’T WORRY. CONSIDER THIS:

GABA is the major inhibitory neurotransmitter in our central nervous system. Thus means that Its main role is to reduce the neural excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. Let’s take an example, when you are sitting on a park bench, relaxing, listening to soft music, and feeling the cool breeze in the air, your nerve cells are at a relatively lower level of activity. Slowly, you can feel a bit sleepy with all the calmness around you. Your body is also relaxed because your nerve cells are not very excited. You decide to sleep on the bench. Now during sleep, you will be aware that the motor movements of your limbs is absent. Thus is made possible by activation of the GABA receptors in the motor neurons which are leading to arms and legs. Thus, your state of inactivity is made possible because of the release of the GABA neurotransmitter inside the nerve cells.  The GABA receptor selectively conducts Chloride ions through its pore, resulting in hyperpolarization of the neuron. This leads to an inhibitory effect by diminishing the chance of a successful action action potential of -70mV.

Just remember this: GABA= Chloride ions( hyperpolarization)= inhibition= Relaxation.