Question

please research about taxine B and provide as much information.

Answer 1

Taxine B is one of the Taxine Alkaloids present in the yew leaves, known as Taxus baccata from Family Taxaceae, which is known for its toxicity and Poisoning nature. The Taxine B constitutes to 30% of the total alkaloid fraction in the leaves of Taxus baccata.

(a) Solubility : -
These are readily soluble in dilute Acids, Chloroform and acetic acid, slighly soluble in water but insoluble in petroleum ether.

(b) Pharmacology : - Taxine B interferes with Sodium and Calcium channels in myocardial cells, thereby increasing their concentration. Taxine B is more cardiotoxic than Taxine A by inducing Ionotropic effects and by changing in AV conduction, rsulting in complete Cardiac arrest. Taxine B is also known for reduction in the maximum rate of depolarization of action potential in papillary muscle.

(c) Toxicity Profile : -
Taxine B is more potent and degree of toxicity depends on the dose.
The following are signs and symptoms of toxicity in animals - Ataxia, Bradycardia, Dyspnea, Muscle tremors, Convulsions, followed by death.
The human beings have symptoms such as Dizziness,Nausea, Vomiting, Pupil dilation, Abdominal pains, Tachycardia, convulsions. These signs may proceed further to bradycardia, bradypnea and death of the patient.

(d) Treatment for Taxine - B toxicity :-
Rumenotomy in animals &/or intramuscular doses of Atropine sulfate or Lidocaine.