Question

You are now working in the ICU. Your current patient was in a nasty car accident last night (dropping liters on the pavement), it is now 12 hours later and your patient is starting to stabilize. You have to figure out all of the possible problems to help your patient recover.

They determined that his blood type was B-. Two of his siblings showed up to donate blood. His sister is type O-; and his brother is type A+. 3 points

​A) How is this possible? Draw the genetic squares (one for ABO and one for Rh +/- to show what genetic types the parents must be. What is the 4th genetic type?

​B) Which sibling is the better blood donor? Why?

Answer 1

PARENTS POSSIBILITY OF CHILDERENS BLOOD GROUP

SUPPOSE MOTHER BLOOD GROUP= AO

FATHER BLOOD GROUP = BO

FATHER --> MOTHER -	B	O
A	AB	AO
O	BO	OO

4 POSSIBILITY OF CHILDERENS BLLOD GROUP :

1. AB

2. AO (BROTHER)

3. BO (PATIENT)

4. OO (SISTER)

Rh TABLE Rh GENE DENOTED BY DD/Dd/dd

CAPITAL D = DOMINENT INHERITANCE

SMALL d= RECESSIVE INHERITANCE

HERE A+ , B-VE AND O-VE

INDICATE THAT ONE OF PARENT HAS RECCESIVE GENE PATTERN FOR Rh THAT IS SMALL D (dd)

OTHER PARENT HAS HETEROGENOUS GENE THAT IS (Dd)

FATHER (dd) --> MOTHER (Dd)-	B	O
A	AB	AO(+)
O	BO(-)	OO (-)

Rh table

FATHER Rh(dd) --> MOTHER Rh(Dd)-	d	d
D	Dd(+)	Dd(+)
d	dd(-)	dd(-)

HENCE 4TH GENETIC TYPE IS AB +VE (Dd)

B.  SISTER IS BETTER DONAR BECAUSE HER BLOOD GROUP IS O-VE

UNIVERSAL DONER BLOOD GROUP

BLOOD GROUP O DENOTE

NO ANTIGEN ON SURFACE OF RED BLOOD CELL

BOTH ANTIBODIES ( ANTI-A & ANTI-B) PRESENT IN PLASMA

HENCE RECEPIENT BLOOD NOT ATTACK RBC OF DONOR BECAUSE DONOR O -VE NOT HAVING ANTIGEN

ON RBC SURFACE .