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In: Biology

While screening for genetic differences that might be related to Autism Spectrum disorder, you discover that...

While screening for genetic differences that might be related to Autism Spectrum disorder, you discover that a pair of siblings with ASD both have variations in the genes for a chloride importer, the potassium leak channel, an AMPA receptor, and a GABA reuptake transporter.

a) What changes in the function of those 4 proteins would you expect to see if they were associated with ASD according to the “Intense World” Theory?

b) For each gene, give an example of how a brain region affected by that variation would affect 1 of the 3 domains of impairments (social, communication, repetitive behavior) common in ASD. (Your answer will have 4 sections, one for each gene, and each section should refer to 1 of the 3 domains of impairments, and 1 specific brain region that might underlie that behavior)

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